Description
Product Characteristics:
Subcellular location: Cytoplasm
Synonyms: EC 6.1.1.21, FLJ20491, HisRS, Jo-1, histidine translase, Histidine tRNA ligase, Histidyl tRNA synthetase, HRS, Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds, SYHC_HUMAN.
Target Information: Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]